It is often suggested that during development the brain barriers are immature. This argument stems from teleological interpretations and experimental observations of the high protein concentrations in fetal cerebrospinal fluid (CSF) and decreases in apparent permeability of passive markers during development. We argue that the developmental blood–CSF barrier restricts the passage of lipid‐insoluble molecules by the same mechanism as in the adult (tight junctions) rendering the paracellular pathway an unlikely route of entry. Instead, we suggest that both protein and passive (...) markers are transferred across the epithelium through a transcellular route. We propose that changes in volume of distribution can largely explain the decrease in apparent permeability for passive markers and that developmentally regulated cellular transfer explains changes in CSF protein concentrations. The blood–CSF tight junctions are functionally mature from very early in development, and it appears that transfer from blood into embryonic brain occurs predominately via CSF rather than the vasculature. BioEssays 30:237–248, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Bovine fetuin, the first fetal protein to be described, has recently been shown to be a species homologue of a well known human plasma protein ‐ α2HS glycoprotein (α2HS). The fetuins are now known to be members of the cystatin superfamily. The structural properties of the six fetuins that have been fully sequenced are compared. Despite the structural homology of these proteins, their described properties in the literature make them appear to be quite different. The diverse in vitro properties claimed (...) for fetuin/α2HS are reviewed. In vivo, fetuins are involved in the acute phase response. In development, in all species studied so far, fetuins are present in a specific cell population that forms the developing neocortex. The possible functional significance of this distribution is discussed. (shrink)

Children with developmental dyslexia and at its risk have difficulties in the acquisition of foreign languages, especially non-transparent English. The problems of such pupils concern various aspects of the language system but in particular relate to the ability to read and spell. The research literature dedicated to effective preventative methods and dyslexia treatment suggests that both children with dyslexia and at its risk need phonological awareness training and multi-sensory learning. It is also known that prevention and early treatment is more (...) effective than therapeutic intervention used in older students. Experts in foreign language acquisition recommend that children have contact with longer oral texts and live language. A recently-published report on the methods of English language teaching in Polish primary schools shows that the lessons conducted there do not realise the majority of the aforementioned recommendations. As a consequence, they do not serve any pupils including those with dyslexia and at its risk. A method which meets most of the demands mentioned above is “The Good Start Method for English”. It is a new program of teaching the English language designed for five to seven-year-olds, which at the same time ensures support for the psychomotor development of children, leading to acceleration in learning progress. (shrink)

Although developmental dyslexia is frequently diagnosed in Poland, little knowledge of effective treatment for this disorder is available in Polish society. Remedial teachers for many years have applied traditional methods aimed at correction and compensation for affected cognitive functions and academic skills. Otherwise, although western therapies are regularly advertised in the media, their effectiveness has rarely been subject to scientific investigation. Since the assumptions underlying some approaches are not consistent with current understanding of cognitive function, they may attract negative expert (...) appraisal. Unfortunately, it seems that fashion in dyslexia therapy is resistant to rare expressions of criticism from the scientific community. The purpose of this article is to promote awareness about effective treatment for specific reading disorders. Teachers’ greater understanding in this area should help Polish dyslexic children and their parents, who may be confused by offers of misguided therapy and sharp business practise. It is hoped that this article will clarify the situation. In this review of modern English journal articles, focus is on remedial teaching of reading, and more specifically, support for dyslexic students experiencing difficulties in decoding. Here we are concerned only with therapy in alphabetic languages in which individual speech sounds correspond to letters. Analysis of articles from the last six years leads to the conclusion that the most effective therapy for the reading disorder is training in phonological awareness and consolidation of letter-sound knowledge. However, these skills should be practised in the context of reading. (shrink)

The aim of this paper is to characterize varieties of Heyting algebras with decidable theory of their finite members. Actually we prove that such varieties are exactly the varieties generated by linearly ordered algebras. It contrasts to the result of Burris [2] saying that in the case of whole varieties, only trivial variety and the variety of Boolean algebras have decidable first order theories.

According to the expertise defense, practitioners of the method of cases need not worry about findings that ordinary people’s philosophical intuitions depend on epistemically irrelevant factors. This is because, honed by years of training, the intuitions of professional philosophers likely surpass those of the folk. To investigate this, we conducted a controlled longitudinal study of a broad range of intuitions in undergraduate students of philosophy (n = 226), whose case judgments we sampled after each semester throughout their studies. Under the (...) assumption, made by proponents of the expertise defense, that formal training in philosophy gives rise to the kind of expertise that accounts for changes in the students’ responses to philosophically puzzling cases, our data suggest that the acquired cognitive skills only affect single case judgments at a time. There does not seem to exist either a general expertise that informs case judgments in all areas of philosophy, or an expertise specific to particular subfields. In fact, we argue that available evidence, including the results of cross-sectional research, is best explained in terms of differences in adopted beliefs about specific cases, rather than acquired cognitive skills. We also investigated whether individuals who choose to study philosophy have atypical intuitions compared to the general population and whether students whose intuitions are at odds with textbook consensus are more likely than others to drop out of the philosophy program. (shrink)

Explainable artificial intelligence has become a vitally important research field aiming, among other tasks, to justify predictions made by intelligent classifiers automatically learned from data. Importantly, efficiency of automated explanations may be undermined if the end user does not have sufficient domain knowledge or lacks information about the data used for training. To address the issue of effective explanation communication, we propose a novel information-seeking explanatory dialogue game following the most recent requirements to automatically generated explanations. Further, we generalise our (...) dialogue model in form of an explanatory dialogue grammar which makes it applicable to interpretable rule-based classifiers that are enhanced with the capability to provide textual explanations. Finally, we carry out an exploratory user study to validate the corresponding dialogue protocol and analyse the experimental results using insights from process mining and argument analytics. A high number of requests for alternative explanations testifies the need for ensuring diversity in the context of automated explanations. (shrink)

Psychobiological responses to music have been examined previously in various naturalistic settings in adults. Choir singing seems to be associated with positive psychobiological outcomes in adults. However, evidence on the effectiveness of singing in children and adolescents is sparse. The COVID-19 outbreak is significantly affecting society now and in the future, including how individuals engage with music. The COVID-19 pandemic is occurring at a time when virtual participation in musical experiences such as singing in a virtual choir has become more (...) prevalent. However, it remains unclear whether virtual singing leads to different responses in comparison with in-person singing. We evaluated the psychobiological effects of in-person choral singing in comparison with the effects of virtual choral singing in a naturalistic pilot within-subject study. A group of children and young adolescents from a school in Salzburg, Austria were recruited to take part in the study. Subjective measures were taken pre- and post-singing sessions once a week. Additionally, salivary biomarkers and quantity of social contacts were assessed pre- and post-singing sessions every second week. Psychological stability, self-esteem, emotional competences, and chronic stress levels were measured at the beginning of in-person singing as well as at the beginning and the end of the virtual singing. We observed a positive impact on mood after both in-person and virtual singing. Over time, in-person singing showed a pre-post decrease in salivary cortisol, while virtual singing showed a moderate increase. Moreover, a greater reduction in stress, positive change in calmness, and higher values of social contacts could be observed for the in-person setting compared to the virtual one. In addition, we observed positive changes in psychological stability, maladaptive emotional competences, chronic stress levels, hair cortisol, self-contingency and quality of life. Our preliminary findings suggest that group singing may provide benefits for children and adolescents. In-person singing in particular seems to have a stronger psychobiological effect. (shrink)

Celem tego artykułu jest analiza znaczeń pojęcia ekosocjalizmu we współczesnym dyskursie filozoficznym i politycznym. W pierwszym kroku przeprowadzam rozróżnienie pomiędzy ekosocjalizmem jako ruchem a ekosocjalizmem jako teorią. Globalny ruch ekosocjalistyczny jednoczą postulaty polityczne. W jego skład wchodzą jednak nurty o różnorodnych założeniach teoretycznych. Skupiam się na opozycji pomiędzy nurtami nawiązującymi do tradycji marksistowskiej a nurtami, które w ślad za Joanem Martinezem-Alierem można nazwać „neonarodnictwem ekologicznym”, czyli odwołującymi się do tradycyjnych etyk i wartości istniejących społeczności, tak jak w przypadku licznych ruchów (...) rdzennych i ekofeministycznych. Nurty te różnią się poglądami na wiele kwestii, w tym na kwestię rozwoju. W drugim kroku, rozważając ekosocjalizm jako teorię, wyróżniam dwa stanowiska. Zgodnie z pierwszym z nich, reprezentowanym przez Joela Kovela i Michaela Löwy’ego, myśl Marksa należy uzupełnić o wymiar ekologiczny. Zgodnie z drugim stanowiskiem, którego przedstawicielem jest John Bellamy Foster, ekosocjalizm to idea Marksowska, przedstawiona w Kapitale. Wysuwając na pierwszy plan pojęcia metabolizmu i rysy metabolicznej, Foster odkrywa ekologiczny, we współczesnym sensie, wymiar myśli dojrzałego Marksa. Wykazuję, że należy odróżnić ekosocjalizm w znaczeniu politycznym od ekosocjalizmu w znaczeniu filozoficznym. Na poziomie filozoficznym natomiast, rozbieżność stanowisk ma swoją genezę w interpretacji ontologii Marksa: Kovel i Löwy są kontynuatorami tradycji marksizmu-humanizmu, a Foster zrywa z tą tradycją i odczytuje ontologię Marksa w perspektywie materializmu epikurejskiego. (shrink)

Objectives Study participants are 46 women with Mayer-Rokitansky-Küster-Hauser syndrome. Occurrence of the M-R-K-H syndrome is one in 4000-5000 female children. It was investigated whether coping styles mediate the effect of neuroticism on positive and negative affect, and whether this mediation is moderated by the level of N as well as whether this moderated mediation is moderated by length of awareness of illness. Methods: Neuroticism, coping style as well as positive and negative emotions were assessed using the Polish version of NOE-FFI, (...) CISS and Scale of Emotional State. Results: Emotion coping style fully or partly mediated the relationship between neuroticism and emotions and these mediations were moderated by the level of N. Additionally, direct effect of neuroticism on NA was moderated by the time for which a patient has been aware of the disease. Conclusions: The level of neuroticism and the length of illness are important factors for the psychological functioning of women with M-R-K-H Syndrome. In women with medium and high neuroticism, effect of N on NA was indirect and also direct - but only in those who have been aware of the diagnosis for 6 years or more. Relations with positive emotions were different: the indirect effect was observed only in women with a moderate and low neuroticism. (shrink)

Na podstawie prześledzenia genezy Dzieci nędzy (1913) i historii komponowania tekstu dokonano ciekawych ustaleń z zakresu działań twórczych najgłośniejszego autora Młodej Polski – Stanisława Przybyszewskiego. Badania ujawniły m.in. niechęć pisarza do (czy może: nieumiejętność) radykalnej modyfikacji raz dokonanych zapisów tekstowych i wzrost literackiej efektywności z dala od wielkich miast. Kolacjonowanie przekazów powieści oraz lektura dokumentów osobistych pozwoliły stwierdzić, że znaczący wpływ na ostateczny kształt Dzieci nędzy miały powikłania osobiste i przykre okoliczności życiowe, które znacząco determinowały (czy raczej: destruowały) proces pisarski (...) Przybyszewskiego, oraz ingerencja domagającego się uzupełnień wydawcy, któremu pisarz skwapliwie przyznał rację, dopisując kilka rozdziałów. Te sumiennie dokonane poprawki świadczą o tym, jak ważne były dla pisarza uwagi redakcyjne w udoskonalaniu tekstu. Najważniejsze odkrycie, do jakiego prowadzą badania tekstologiczne, dotyczy jednak autorskiej rezygnacji z zamierzonego pierwotnie poematu prozą i przetransponowania jego idei w formę powieściową. Ta decyzja – będąca rodzajem kapitulacji w zmaganiach z tworzywem – świadczyła de facto o nowatorskim myśleniu Przybyszewskiego o powieści i sprawiła, że Dzieci nędzy to niezwykle ciekawy artystycznie, nowoczesny zapis stanów psychicznych. Od strony rozwiązań konstrukcyjno-narracyjnych to niewątpliwie jedna z najciekawszych powieści Przybyszewskiego. (shrink)

Sidgwick's defence of esoteric morality has been heavily criticized, for example in Bernard Williams's condemnation of it as 'Government House utilitarianism.' It is also at odds with the idea of morality defended by Kant, Rawls, Bernard Gert, Brad Hooker, and T.M. Scanlon. Yet it does seem to be an implication of consequentialism that it is sometimes right to do in secret what it would not be right to do openly, or to advocate publicly. We defend Sidgwick on this issue, and (...) show that accepting the possibility of esoteric morality makes it possible to explain why we should accept consequentialism, even while we may feel disapproval towards some of its implications. (shrink)

Zmiany dokonujące się w języku na przestrzeni dziejów są wynikiem zmian w rzeczywistości pozajęzykowej. Nowe elementy leksyki są m. in. efektem procesu zapożyczenia z innych języków. Słowa te w momencie przejmowania ich przez inny język tracą swe wszelkie pierwotne powiązania z innymi leksemami, które miały w języku, z jakiego zostały przejęte, i wchodzą w nowe relacje semantyczne z istniejącymi już w danym poiu wyrazowym słowami, stając się jego nieodłącznym elementem. W procesie asymilacji na płaszczyźnie semantycznej wchodzą one w nowe dla (...) siebie relacje paradygmatyczne i syntagmatyczne, wpływając znacząco na strukturę danego pola wyrazowego i przyczyniając się do zmian w jego obrębie. Zapożyczone z innego języka wyrazy mogą ze względu na swe znaczenie stać się w danych polach elementami dominującymi lub też pojawić się w nowym otoczeniu leksykalnym obok rodzimych synonimów. Jedynie użytkownik języka, przy uwzględnieniu kontekstu językowego i sytuacyjnego, decyduje o ich użyciu. (shrink)

We współczesnej polszczyźnie występuje wiele słów, będących zapożyczeniami z języka niemieckiego. Najstarsze zapożyczenia pojawiły się w języku polskim wraz z nowymi przedmiotami codziennego użytku i były jednocześnie zapożyczeniami fonetycznymi. Obecnie nie wyczuwa się już ich obcego pochodzenia. Słowa przejęte z niemieckiego podlegały w języku polskim licznym i różnorodnym procesom adaptacyjnym, dotyczącym m. in. ich formy gramatycznej, fonetycznej czy też morfologii. Ulegały one również licznym zmianom znaczeniowym, tzn. rozszerzały bądź zawężały swe pierwotne znaczenie, zmieniały również zabarwienie stylistyczne. Poza tym można też (...) mówić o przesunięciu znaczenia wyrazu zapożyczonego oraz o zjawisku przejmowania tylko niektórych znaczeń pierwotnych danego słowa, pochodzącego z języka niemieckiego. Ciekawym zjawiskiem jest również występowanie we współczesnej polszczyźnie takich wyrazów niemieckiego pochodzenia, które jednak nie posiadają już swych odpowiedników we współczesnym języku niemieckim, tzn. w nowo-wysoko-niemieckim, gdyż zostały one zapożyczone bardzo dawno, ale znaleźć je można jeszcze w słownikach etymologicznych języka polskiego, gdzie podawane są jak o odpowiedniki niemieckie danych wyrazów, np. fastryga, framuga itd. Całkowite podporządkowanie się regułom języka przejmującego dany wyraz obcego pochodzenia świadczy o jego zakorzenieniu się w danym języku oraz dopasowaniu się do nowego systemu językowego. Wyrazy pochodne od danego zapożyczenia, frazeologizmy, w których te zapożyczenia występują, synonimy, pojawiające się w danym języku obok wyrazów zapożyczonych oraz frekwencja zapożyczeń w danym języku świadczą o stopniu zakorzenienia się danego wyrazu obcego pochodzenia w języku polskim. (shrink)

The paper is a reaction to M. Grygianiec’s reply in a discussion sparked on by his paper on the status of the epiphenomenalism objection. I correct some misunderstandings. In addition I offer an intuitive summary of my reconstruction of the debate. I show that Grynianiec’s reply does not undermine the reconstruction. I argue that to the extent that (external) praise of Davidson’s ideas is possible, so is external criticism. Moreover, I argue that interpretative charity demands a charitable stance not only (...) to Davidson but also to his critics. (shrink)

The paper is a critical reaction to M. Grygianiec’s discussion of the status of the epiphenomenalism objection to anomalous monism. Grygianiec argues that the objection does not arise for Davidson if one takes his nominalism seriously. I show that Grygianiec construes the epiphenomenalism charge as an internal one. I argue that it can be viewed as an external objection to anomalous monism, moreover one that is justified, adequate and charitable. I distinguish two interpretations of the objection and show that an (...) appeal to charity can explain why an apparently inadequate form the objection is often preferred. (shrink)

Contemporary axiological research shows that what is intuitive, perceptible, and at the same time fundamental, is not clearly visualized, concrete and expressible for language. The problem of the definition of value is further complicated when the matter concerns the top of the axiological ladder, absolute value, what is sacred. In the article, the author relies mainly on the achievements of eminent phenomenologists, theologians and religious studies scholars who had a decisive influence on the European understanding of the term sacrum (including (...) R. Otto, M. Scheler, G. van der Leeuw, M. Eliade). It also refers to the achievements of Polish philosophers. The sacrum is presented as a factor ordering reality in an axiological and ontological sense. The very search for the highest value appears to be a matter of the utmost importance, a special task facing homo religiosus. (shrink)

Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis which has infected one third of the mankind and causes 2–3 million deaths worldwide each year. The persistence of the infection ensues from the ability of M. tuberculosis to subvert host immune responses in favor of survival and growth of mycobacteria in macrophages. The mechanisms by which M. tuberculosis manipulates the host immune system have only recently come to light. These activities are attributed to lipoarabinomannans (LAM) and their precursors lipomannans (LM), (...) two predominant glycolipids of M. tuberculosis cell wall. LM are able to skew anti‐mycobacterial immune responses into un‐protective ones, while LAM evoke immunosupression upon binding to macrophage and dendritic cell receptors specialized in binding to “self” host components. A newly emerging idea implicates plasma membrane rafts in LM and LAM signaling. Depending on acylation patterns, the glycolipids may either directly incorporate into the raft membrane via mannosylphosphatidylinositol anchors or interact with raft‐associated proteins to affect the assembly of receptor signaling complexes. BioEssays 30:943–954, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

Microbiota-gut-brain research is a fast-growing field of inquiry with important implications for how human brain function and behaviour are understood. Researchers manipulate gut microbes to reveal connections between intestinal microbiota and normal brain functions or pathological states. Many claims are made about causal relationships between gut microbiota and human behaviour. By uncovering these relationships, MGB research aims to offer new explanations of mental health and potential avenues of treatment. So far, limited evaluation has been made of MGB's methods and its (...) core experimental findings, many of which are extensively reiterated in copious reviews of the field. These factors, plus the self-help potential of MGB, have combined to encourage uncritical public uptake of MGB discoveries. Both social and professional media focus on the potential for dietary intervention in mental health, and causal relationships are assumed to be established. Our target article has two main aims. One is to examine critically the core practices and findings of experimental MGB research and to raise questions about them for brain and behavioural scientists who may not be familiar with the field. The other is to challenge the way in which MGB findings are presented. Our positive goal is to suggest how current problems and weaknesses may be addressed, in order for both scientific and public audiences to gain a clearer picture of MGB research and its strengths and limitations. (shrink)

The paper investigates the various factors from a socio-cultural perspective that have a bearing on the intercultural couple’s marital satisfaction in Westerner and non-Westerner relationships, and how cultural differences may potentially amplify the difficulties, which non-intercultural couples themselves are already likely to face. These factors include acculturation, language and communication, attitudes toward marriage, individual traits and behaviours, support of the family, societal views, gender roles, managing of the household finances and child rearing. Certain theories are also highlighted in an attempt (...) to explain why these cultural differences have such a profound effect on the marital satisfaction of intercultural couples. (shrink)

Focusing on the analysis of Athens' relations with both Greeks and non-Greeks as recorded in extant fourth-century decrees, this paper challenges the applicability of the notion of Greek/barbarian antithesis to the interpretation of formal diplomatic exchanges between Athens and the non-Greek states. A comparison of the types of decrees and honors reveals a remarkable uniformity in the forms of Athens' foreign relations irrespective of the ethnicity of honorands. The distribution of honors among individuals and groups of recipients within single decrees (...) further demonstrates that the Athenian honorific system typically elevated individuals over communities they represented, suggesting that political differences between Athens and non-Greek states did not adversely influence the methods of exchanges between them. Apart from the provisions contained in the decrees, this paper also considers their function within the city as monuments that attest to the important place of philobarbaric discourse and practice in fourth-century Athens. (shrink)

People differ in the extent to which they express a need for sense-making, and these individual differences are important to understand in light of meaning-making processes. To quantify this important variable, we originally proposed a need for sense-making scale. We now propose a refined, similarly reliable short version of the scale. The 7-item NSM-SF was validated across a series of four studies. NSM-SF showed psychometric properties and correlations consistent with its longer forerunner. Additionally, results indicated that the need for sense-making (...) was moderately positively related to the satisfaction of basic psychological needs, and it related negatively to the frustration of these needs. The research offers a useful, brief tool for assessing the NSM construct and broadens our understanding of basic psychological motivations. (shrink)